| Dentrix | Henry Schein One | On-premise Windows server (SQL Server) | Single office; Dentrix Enterprise exists for groups1 | Via integrated partners in the Henry Schein ecosystem |
| Dentrix Ascend | Henry Schein One | Cloud-native, browser-based; a separate codebase from Dentrix1 | Built for multi-site: central database, cross-location reporting2 | Cloud imaging in-platform |
| Eaglesoft | Patterson Dental | On-premise server | Single office3 | Built-in digital imaging integration |
| Fuse | Patterson Dental | Cloud (launched 2018)4 | Consolidates multi-location data; real-time central scheduling and reporting | Integrated eServices/imaging |
| Open Dental | Open Dental Software | On-premise client-server, MySQL; proprietary license since v24.4 (GPL before)5 | Any size, including large DSOs, via hosted MySQL plus the API; write access is API-only6 | Third-party imaging bridges |
| Curve Dental (SuperHero) | Curve Dental | Cloud (AWS), all-in-one | Start-ups, single offices, and multi-location groups; consolidated cross-location dashboards7 | Native cloud imaging and charting |
| Denticon | Planet DDS | Cloud, multi-tenant, built for groups from the start | Positions itself as the enterprise-DSO leader. See the vendor-claim note below8 | Apteryx XVWeb (Planet DDS-owned imaging) |
| tab32 | tab32 | Cloud | Targets multi-location groups and DSOs; from roughly $$125/month9 | Built-in, with AI radiology |
| Archy | Archy | Cloud, all-in-one (imaging, communications, payroll via Gusto)10 | Primarily single offices and small groups; per-location pricing, unlimited users | Built-in real-time imaging plus a Pearl AI integration |
| Oryx | Oryx Dental Software | Cloud | Single practices and small groups; known for clinical-content depth and migrations from 50+ platforms11 | In-platform |